Neurobiology of Disease Aggregated, Wild-Type Prion Protein Causes Neurological Dysfunction and Synaptic Abnormalities
نویسندگان
چکیده
Roberto Chiesa,1 Pedro Piccardo,2,3 Emiliano Biasini,1,4 Bernardino Ghetti,2 and David A. Harris4 1Dulbecco Telethon Institute and Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20156, Milan, Italy, 2Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, 3Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852, and 4Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110
منابع مشابه
Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities.
The neurotoxic forms of the prion protein (PrP) that cause neurodegeneration in prion diseases remain to be conclusively identified. Considerable evidence points to the importance of noninfectious oligomers of PrP in the pathogenic process. In this study, we describe lines of Tg(WT) transgenic mice that over-express wild-type PrP by either approximately 5-fold or approximately 10-fold (dependin...
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تاریخ انتشار 2008